InhaltsangabeABOUT THE EDITORS vii CONTRIBUTORS ix INTRODUCTION 1 1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3 GuoQiang Lin, JianGe Zhang, and JieFei Cheng 2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29 GuoQiang Lin and XingWen Sun 3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77 Jianqiang Wang and Wenya Lu 4 RESOLUTION OF CHIRAL DRUGS 137 QiDong You 5 FLUORINECONTAINING CHIRAL DRUGS 195 XiaoLong Qiu, Xuyi Yue, and FengLing Qing 6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253 HuiYin (Harry) Li, Rui Liu, Carl Behrens, and ChaoYing Ni 7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297 Deping Wang and Eric Hu 8 PHARMACOLOGY OF CHIRAL DRUGS 323 Yongge Liu and Xiao-Hui Gu 9 PHARMACOKINETICS OF CHIRAL DRUGS 347 Hanqing Dong, Xiaochuan Guo and Zengbiao Li 10 TOXICOLOGY OF CHIRAL DRUGS 381 Guang Yang and Hai-Zhi Bu 11 REPRESENTATIVE CHIRAL DRUGS 401 Jiangqin Sun, Dingguo Liu, and Zhimin Wang INDEX 449

GUO-QIANG LIN, is a professor at the Shanghai Institute of Organic Chemistry and an adjunct professor at Fudan University, China. He is the Director of the Division of Chemical Science of the National Natural Science Foundation of China. Among Professor Lin's publications are the Wiley books Principles and Applications of Asymmetric Synthesis and Biocatalysis for the Pharmaceutical Industry. QIDONG YOU, PHD, is the Dean and a professor of the School of Pharmacy at China Pharmaceutical University. He is an Associate Editor of Progress in Pharmaceutical Sciences and serves on the Editorial Board of the International Journal of Medicinal Chemistry and Acta Pharmaceutica Sinica. Dr. You is a coauthor of over eighty publications, and an inventor or coinventor of over twenty patent applications and patents. JIEFEI CHENG, PHD, is the Director of Otsuka Shanghai Research Institute, a fully owned subsidiary of Otsuka Pharmaceutical Co., Ltd Japan. Formerly an associate professor at Shanghai Institute of Organic Chemistry, he has worked for over fifteen years in the pharmaceutical and biotech industries in the United States. Dr. Cheng is a coauthor of over fifty peerreviewed publications, and an inventor or coinventor of over twenty patent applications and patents.

Leseprobe

Chapter 1. Overview of chirality and chiral drugs (Guo-Qiang Lin, Jiange Zhang and Jie-Fei Cheng). Chapter 2. Chiral drugs through asymmetric synthesis (Guo-Quiang Lin and Xing-Wen Sun). Chapter 3. Chiral drugs via biocatalytical approaches (Jianqiang Wang and Wenya Lu). Chapter 4. Chiral resolution (Qi-Dong You). Chapter 5. Fluorine-containing chiral drugs (Xiao-Long Qiu, Xuyi Yue and Feng-Ling Qing). Chapter 6. Industrial application of chiral technologies (Hui-Ying (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni). Chapter 7. Computation modeling study on mechanism-of-action of chiral drugs (Deping Wang and Eric Gu). Chapter 8. Pharmacology of chiral drugs (Yongge Liu and Xiao-Hui Gu). Chapter 9. Pharmacokinetics of chiral drugs (Hanqing Dong, Xiaochuan Guo and Zengbiao Li). Chapter 10. Toxicology of chiral drugs (Guang Yang and Hai-Zhi Bu). Chapter 11. Representative chiral drugs (Jiangqin Sun, Dingguo Liu and Zhimin Wang).