Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

Mike S. Lee is President of Milestone Development Services where he consults and develops workshops and symposia to support industry with innovative technologies and solutions. His research interests include the application of mass spectrometry for the analysis of proteins, natural products, drug metabolites, impurities, and degradants. Recently, he has been involved in the development of automated orthogonal control systems for electrospray ionization and the development of digital separation devices for sampling, separation, and enrichment.

Leseprobe

InhaltsangabeFOREWORD xi PREFACE xiii CONTRIBUTORS xvii SECTION I BIOTECHNOLOGY/PROTEINS 1 1 Targeted Proteomics Using Immunoaffi nity Purifi cation 3 Karen R. Jonscher, Lei Jin, John C. Cambier, Shaikh M. Rahman, and Jacob E. Friedman 2 Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifi cations by Lipid Peroxidation Products 23 Navin Rauniyar and Laszlo Prokai 3 Imaging Mass Spectrometry (IMS) for Biological Application 41 Yuki Sugiura, Ikuko Yao, and Mitsutoshi Setou 4 Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs 85 George W. Jackson, Rafal Drabek, Mithil Soni, Roger McNichols, Richard C. Willson, and George E. Fox SECTION II PHARMACEUTICAL 107 5 Preclinical Pharmacokinetics: Industrial Perspective 109 Ayman ElKattan and Manthena Varma 6 LCMS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective 119 Wenying Jian, Wilson Shou, Richard W. Edom, Naidong Weng, and Mingshe Zhu 7 Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies 171 Xiaoying Xu, Wenkui Li, and Francis L.S. Tse 8 Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS 191 Margrét Thorsteinsdóttir, Baldur Bragi Sigur?sson, and Gísli Bragason 9 Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS 209 Kevin A. Schug 10 Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture, Dynamics, and Interactions of Biopharmaceutical Products 227 Igor A. Kaltashov, Cedric E. Bobst, and Rinat R. Abzalimov 11 TOFSIMS Applications to Bioimaging and Biomolecule Evaluation Methods 243 Satoka Aoyagi 12 Accelerator Mass Spectrometry in Pharmaceutical Development 259 Benjamin J. Stewart, Graham Bench, Bruce A. Buchholz, Kurt W. Haack, Michael A. Malfatti, Ted J. Ognibene, and Kenneth W. Turteltaub SECTION III CLINICAL ANALYSIS 271 13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism 273 Donald H. Chace 14 Mass Spectrometry for Steroid Analysis 297 William J. Griffi ths, Michael Ogundare, Anna Meljon, and Yuqin Wang SECTION IV FORENSICS 339 15 Forensic Applications of Isotope Ratio Mass Spectrometry 341 Sarah J. Benson 16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry 373 Michael E. Sigman and C. Douglas Clark SECTION V SPACE EXPLORATION 389 17 Mass Spectrometry in Solar System Exploration 391 Paul V. Johnson, Luther W. Beegle, and Isik Kanik 18 Application of GC × GC-TOFMS to the Characterization of Extraterrestrial Organic Matter 407 Jonathan S. Watson SECTION VI HOMELAND SECURITY 417 19 Methods of Mass Spectrometry in Homeland Security Applications 419 Ünige A. Laskay, Erin J. Kaleta, and Vicki H. Wysocki 20 Homeland Security 441 Christina L. Crawford and Herbert H. Hill, Jr. 21 Mass Spectrometry in Homeland Security 477 Yasuaki Takada 22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer 491 Gary S. Groenewold, Anthony D. Appelhans, Garold L. Gresham, and John E. Olson 23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios 509 R. Steven Pappas SECTION VII FOOD ANALYSIS 529 24 Mass Spectrometry in Agriculture, Food, and Flavors: Selected Applications 531 Maciej Stobiecki, Piotr Kachlicki, and Henryk Jeleñ 25 TopDown Proteomic Identifi cation of Protein Biomarkers of FoodBorne Pathogens Using MALDITOFTOFMS/MS 559 Clifton K. Fagerquist and Omar Sultan SECTION VIII ENVIRONMENTAL 575 26 Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry 577 Wolfgang Schwack 27 Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry 593 Chongzheng Na and Terese M. Olson 28 Proton Transfer Reaction Mass Spectrometry (PTR-MS)